"Genomic organization of a human 5beta-reductase and its pseudogene and substrate selectivity of the expressed enzyme". ^ Charbonneau A, The VL (January 2001)."Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. "Identification of cortisone 5 beta-reductase as delta 4-3-ketosteroid 5 beta-reductase". ^ Furuebisu M, Deguchi S, Okuda K (March 1987).The Journal of Steroid Biochemistry and Molecular Biology. "Purification of 5 beta-reductase from hepatic cytosol fraction of chicken". ^ Sugimoto Y, Yoshida M, Tamaoki B (December 1990). ![]() "The enzymatic reduction of delta 4-3-ketosteroids". "Enzymatic introduction of double bonds into steroid ring A". "The delta4-hydrogenases of guinea pig adrenal gland". ^ Brown-Grant K, Forchielli E, Dorfman RI (May 1960)."Separation of delta 4-5 alpha-hydrogenases from rat liver homogenates". ^ Dorfman RI, Forchielli E (November 1956). ![]() It can also act on aldosterone, corticosterone and cortisol, to some extent. The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. This enzyme catalyses the following chemical reaction (1) 5β-cholestan-3-one + NADP + ⇌ cortisone + NADPH + H + 5β-Reductase, or Δ 4-3-oxosteroid 5β-reductase ( EC 1.3.1.3, 3-oxo-Δ 4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ 4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ 4-3-ketosteroid 5β-reductase, Δ 4-5β-reductase, Δ 4-hydrogenase, 4,5β-dihydrocortisone:NADP + Δ 4-oxidoreductase, 3-oxo-5β-steroid:NADP + Δ 4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP + 4,5-oxidoreductase.
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